|
課程資訊 |
|
課程名稱 |
族群遺傳學 Population Genetics | ||||||||||||||||
|
開課學期 |
102-1 | ||||||||||||||||
|
授課對象 |
醫學院 臨床醫學研究所 | ||||||||||||||||
|
授課教師 |
|||||||||||||||||
|
課號 |
ClinMD7048 | ||||||||||||||||
|
課程識別碼 |
421 M3300 | ||||||||||||||||
|
班次 |
|||||||||||||||||
|
學分 |
3 | ||||||||||||||||
|
全/半年 |
半年 | ||||||||||||||||
|
必/選修 |
選修 | ||||||||||||||||
|
上課時間 |
星期四2,3,4(9:10~12:10) | ||||||||||||||||
|
上課地點 |
|||||||||||||||||
|
備註 |
總人數上限：10人 | ||||||||||||||||
|
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1021pop_gen | ||||||||||||||||
|
課程簡介影片 |
|||||||||||||||||
|
核心能力關聯 |
核心能力與課程規劃關聯圖 | ||||||||||||||||
|
課程大綱
|
|||||||||||||||||
|
為確保您我的權利,請尊重智慧財產權及不得非法影印
|
|||||||||||||||||
|
課程概述 |
本課程專為對基因及基因體演化有興趣的學生設計，目標為介紹族群遺傳學的基本理論及如何以族群遺傳的角度解釋分子資料。在本課程中，我們將討論塑造遺傳多樣性的演化力量及過程，估算自然界族群遺傳多樣性的方法，以及對族群遺傳與基因體資料中重要徦說的測試。 | ||||||||||||||||
|
課程目標 |
The course aims to introduce basic theory of population genetics and how molecular data are interpreted within this framework. | ||||||||||||||||
|
課程要求 |
選修本課程的學生應具有代數及微積分的基本能力。 | ||||||||||||||||
|
預期每週課後學習時數 |
|||||||||||||||||
|
Office Hours |
另約時間 | ||||||||||||||||
|
指定閱讀 |
An Introduction to Population Genetics: Theory and Applications, Rasmus Nielsen and Montgomery Slatkin (Sinauer, 2013)
Evolution in Health and Disease (2nd edition), by Stephen Stearns and Jacob Koella (Oxford, 2008) Principles of Evolutionary Medicine, by Peter Gluckman, Alan Beedle, and Mark Hanson, (Oxford, 2009) Human Genetic Diversity, by Julian Knight (Oxford, 2009) |
||||||||||||||||
|
參考書目 |
Population Genetics, by Matthew B. Hamilton (Wiley-Blackwell, 2009)
Principles of Population Genetics, (4th Edition) by Daniel L. Hartl and Andrew G. Clark (Sinauer, 2006) Population Genetics and Microevolutionary Theory by Alan R. Templeton (Wiley-Liss, 2006) Theoretical population genetics, a draft text by Joseph Felsenstein (http://evolution.genetics.washington.edu/pgbook/pgbook.html) | ||||||||||||||||
|
評量方式 (僅供參考) |
| ||||||||||||||||
課程進度 |
|
週次 |
日期 |
單元主題 |
|
第1週 |
9/12 | Introduction/Thinking like a population geneticist |
|
第2週 |
9/19 | Break |
|
第3週 |
9/16 | Genotype and haplotype frequencies in pathogen population |
|
第4週 |
10/03 | Genetic drift and effective population size - focused on pathogen population |
|
第5週 |
10/10 | Break |
|
第6週 |
10/17 | Population structure and gene flow - focused on pathogen population among and within hosts |
|
第7週 |
10/24 | Mutation - focused on raise and fall of pathogen mutations |
|
第8週 |
10/31 | Fundamentals of natural selection |
|
第9週 |
11/7 | Midterm |
|
第10週 |
11/14 | Further models for natural selection- focused on selection between different pathogen strains |
|
第11週 |
11/21 | Further models for natural selection - focused in host parasite interaction |
|
第12週 |
11/28 | Molecular evolution |
|
第13週 |
12/05 | Quantitative trait variation and evolution |
|
第14週 |
12/12 | The Mendelian basis of quantitative trait variation |
|
第15週 |
12/19 | Population Genomics - focused on pathogen genomes |
|
第16週 |
12/26 | Human population genetics-1 |
|
第17週 |
1/03 | Human population genetics-2 |
|
第18週 |
1/09 | Final |